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Across Stages of Life, Ubiquinol Plays an Essential Role

Ubiquinol, the active antioxidant form of coenzyme Q10 (CoQ10), is vital to the production of cellular energy and neutralizing oxidative stress.1-4 These factors influence health and well-being at any age and play a key role in wellness goals from promoting reproductive health to managing menopause and supporting exercise activity.

Explore these health areas and life stages to discover how your patients may benefit from supplementation with Kaneka Ubiquinol®.

Cardiovascular Health

Kaneka Ubiquinol® supports healthy cellular function and antioxidant activity, aiding physiological processes linked to cardiovascular health4,5

  • Facilitates endothelial function and promotes healthy vasodilation by enhancing nitric oxide production4
  • Protects LDL cholesterol from oxidative modification, supporting vascular integrity and circulation4
  • Replenishes CoQ10 levels depleted by statin medications6
  • Improves blood markers associated with cardiovascular wellness, as demonstrated in clinical research7
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Mitochondrial Function

More than a powerhouse: mitochondria are central to cellular resilience, maintenance, and performance8,9

Recent research has led to mitochondria being deemed the “CEO: Chief Executive Organelle” of the cell, responsible for regulating complex metabolic networks, signaling, innate immunity, cell division, and cell fate.8,9

Kaneka Ubiquinol® provides foundational support for healthy mitochondria and cellular function, helping to:

  • Support cellular energy generation3
  • Neutralize reactive oxygen species (byproducts of mitochondrial energy generation) at the source2,10
  • Protect lipids from peroxidation and associated damage10,11
  • Maintain mitochondrial membrane integrity2,10
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Healthy Aging

Kaneka Ubiquinol® supports physiological processes essential for maintaining long-term wellness

  • Ubiquinol levels decline with age, contributing to oxidative stress12
  • Oxidative stress may also be exacerbated by lifestyle factors, such as diet and smoking,13 contributing to premature aging
  • Supplementation with Kaneka Ubiquinol® helps to counteract the impacts of oxidative stress by replenishing ubiquinol levels14
  • Clinical research demonstrates that higher total serum CoQ10 and ubiquinol levels support muscle health and physical functioning impacted by aging15,16
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Sports and Exercise

Kaneka Ubiquinol® supports energy metabolism and cellular wellness during exercise17

  • Promotes a healthy oxidative balance17
  • Supports energy metabolism18
  • Reduces fatigue and supports cardiorespiratory function when training at high altitudes18,19
  • Enhances peak power production in elite athletes when taken at 300 mg/day20
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Menopause

Kaneka Ubiquinol® supports general health and well-being during and after menopause21,22

  • Estrogen, which acts as a powerful antioxidant known to protect lipids from peroxidation, declines in menopause23
  • Oxidative stress has been shown to increase following menopause23,24
  • In a consumer use study, 80% of postmenopausal women taking Kaneka Ubiquinol® 200 mg/day for 60 days reported feeling reduced irritability, sensitivity, stress, and mood swings21
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Preconception

Kaneka Ubiquinol® promotes male and female reproductive health25-28

  • Supports sperm count and motility25,26
  • Promotes mitochondrial energy synthesis,3 important for oocyte health
  • Neutralizes oxidative stress caused by excess reactive oxygen species, known to impact reproductive health in men and women27,28

Visit our site dedicated to preconception health to find out more.

REFERENCES: 1. Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol. 2007;37(1):31-37. 2. Ernster L, Forsmark-Andrée P. Ubiquinol: an endogenous antioxidant in aerobic organisms. Clin Investig. 1993;71(8 Suppl):S60-S65. 3. Martini FH. Metabolism, nutrition, and energetics. In: Fundamentals of Anatomy and Physiology, 12th ed. Prentice Hall; 2024:943-950. 4. Sabbatinelli J, Orlando P, Galeazzi R, et al. Ubiquinol ameliorates endothelial dysfunction in subjects with mild-to-moderate dyslipidemia: a randomized clinical trial. Nutrients. 2020;12(4):1098. 5. Pallotti F, Bergamini C, Lamperti C, Fato R. The roles of coenzyme Q in disease: direct and indirect involvement in cellular functions. Int J Mol Sci. 2021;23(1):128. 6. Zlatohlavek L, Vrablik M, Grauova B, Motykova E, Ceska R. The effect of coenzyme Q10 in statin myopathy. Neuro Endocrinol Lett. 2012;33 Suppl 2:98-101. 7. Onur S, Niklowitz P, Jacobs G, et al. Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans. BMC Res Notes. 2014;7:427. 8. Picard M, Shirihai OS. Mitochondrial signal transduction. Cell Metab. 2022;34(11):1620-1653. 9. Lee-Glover LP, Picard M, Shutt TE. Mitochondria – the CEO of the cell. J Cell Sci. 2025;138(9):jcs263403. 10. Bentinger M, Brismar K, Dallner G. The antioxidant role of coenzyme Q. Mitochondrion. 2007;7(suppl):S41-S50. 11. Stocker R, Bowry VW, Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci U S A. 1991;88(5):1646-1650. 12. Wada H, Goto H, Hagiwara S, Yamamoto Y. Redox status of coenzyme Q10 is associated with chronological age. J Am Geriatr Soc. 2007;55(7):1141-1142. 13. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010;4(8):118-126. 14. Hosoe K, Kitano M, Kishida H, et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007;47(1):19-28. 15. Fischer A, Onur S, Niklowitz P, et al. Coenzyme Q10 status as a determinant of muscular strength in two independent cohorts. PLoS One. 2016;11(12):e0167124. 16. de la Bella-Garzón R, Fernández-Portero C, Alarcón D, Amián JG, López-Lluch G. Levels of plasma coenzyme Q10 are associated with physical capacity and cardiovascular risk in the elderly. Antioxidants (Basel). 2022;11(2):279. 17. Sarmiento A, Diaz-Castro J, Pulido-Moran M, et al. Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: a randomized trial. Biofactors. 2016;42(6):612-622. 18. Lv H, Liu Z, Sun M, et al. Cardiorespiratory fitness and effects of ubiquinol during high-altitude acclimatization and deacclimatization: The SCARF trial. iScience. 2025;28(3):112112. 19. Liu Z, Yang J, Yang B, et al. Effect of ubiquinol on electrophysiology during high-altitude acclimatization and de-acclimatization: a substudy of the Shigatse CARdiorespiratory fitness (SCARF) randomized clinical trial. Int J Cardiol. 2024;401:131817. 20. Alf D, Schmidt ME, Siebrecht SC. Ubiquinol supplementation enhances peak power production in trained athletes: a double-blind, placebo controlled study. J Int Soc Sports Nutr. 2013;10:24. 21. Kaneka Internal Report. Real-life UBIQUINOL study on 200 postmenopausal women. Expansion Consulteam. 2024. 22. Palacios S, Ramírez M, Lilue M, Barahona S, Rodríguez D. Estudio clínico para conocer la eficacia de la coenzima Q10 sobre la calidad de vida en mujeres postmenopáusicas. Toko-Gin Pract. 2019.78(1):3-7. 23. Vincent J, Inassi J. Comparison of oxidative stress between premenopausal and postmenopausal women. Nat J Physiol Pharm Pharacol. 2020;10(5):359-362. 24. Heravi AS, Michos ED, Zhao D, et al. Oxidative stress and menopausal status: the Coronary Artery Risk Development in Young Adults cohort study. J Womens Health (Larchmt). 2022;31(7):1057-1065. 25. Thakur AS, Littarru GP, Funahashi I, Painkara US, Dange NS, Chauhan P. Effect of ubiquinol therapy on sperm parameters and serum testosterone levels in oligoasthenozoospermic infertile men. J Clin Diagn Res. 2015;9(9):BC01-BC3. 26. Cakiroglu B, Eyyupoglu SE, Gozukucuk R, Uyanik BS. Ubiquinol effect on sperm parameters in subfertile men who have astheno-teratozoospermia with normal sperm concentration. Nephrourol Mon. 2014;6(3):e16870. 27. Agarwal A, Parekh N, Panner Selvam MK, et al. Male oxidative stress infertility (MOSI): proposed terminology and clinical practice guidelines for management of idiopathic male infertility. World J Mens Health. 2019;37(3):296-312. 28. Mihalas BP, Redgrove KA, McLaughlin EA, Nixon B. Molecular mechanisms responsible for increased vulnerability of the ageing oocyte to oxidative damage. Oxid Med Cell Longev. 2017;2017:4015874.